AS-60524, PI 3-Kinase inhibitor (TBI2575)
$90.00 – $342.00
PI 3-Kinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2575-5MG | Yes | 5 MG | $90.00 | |||
TBI2575-25MG | Yes | 25 MG | $342.00 |
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Description
Product Details
Formal Name: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
Molecular Formula: C12H7N3O2S
Formula Weight: 257.27
CAS Number: 648450-29-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 1.5 m g/ml with warming)
Storage: -20°C
Stability: ≥ 2 years.
Applications
PI 3-Kinase inhibitor
Functions
Potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ ), IC50 = 8 nM displaying 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα. Suppresses joint inflammation in two distinct mouse models. Ameliorates surgical brain injury, colitis, intimal hyperplasia-induced inflammatory processes and renal injury/fibrosis in rodent models. Orally active.
Application Procedures
First dissolved in DMSO (up to 1.5 m g/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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