AR7, Activates chaperone mediated autophagy (TBI5515)
$126.00 – $504.00
Activates chaperone mediated autophagy
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5515-5MG | Yes | 5 MG | $126.00 | |||
TBI5515-25MG | Yes | 25 MG | $504.00 |
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Description
Product Details
Formal Name: 7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine
Molecular Formula: C15H12ClNO
Formula Weight: 257.70
CAS Number: 80306-38-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (30 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Activates chaperone mediated autophagy
Functions
Atypical retinoid that acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway. Downstream signaling results in an increase of LAMP-2A expression. Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model. AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease-modifying strategy in Parkinson’s disease. A targetome analysis of AR7-induced CMA in cancer cells has been performed.
Application Procedures
First dissolved in DMSO (30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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