AP39, Mitochondrial-targeted hydrogen sulfide donor (TBI3916)

Description

Product Details

Formal Name: (10-Oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide

Molecular Formula: C₃₇H₃₈BrO₂PS₃

Formula Weight: 721.77

CAS Number: 1429173-57-8

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (35 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Mitochondrial-targeted hydrogen sulfide donor

Functions

AP39 is a mitochondrially targeted hydrogen sulfide donor.  At lower concentrations (30-100 nM), it acts as an electron donor and stimulator of mitochondrial electron transport and ATP production. AP39 displayed antioxidant and cytoprotective effects in oxidatively stressed endothelial cells. It displayed protective effects in various pathological states including renal injury, Alzheimer’s, ischemia, and reperfusion injury.  Improves outcomes in subnormothermic organ preservation models.

Application Procedures

First dissolved in DMSO (35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month. Hygroscopic! Protect from moisture and air.

Research use only.

Additional information

Datasheet:

TBI3916-AP39_Datasheet

MSDS:

TBI3916-AP39_MSDS

Research use only.