Allopregnanolone, GABA-A positive allosteric modulator (TBI3489)
$126.00 – $504.00
GABA-A positive allosteric modulator
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3489-5MG | Yes | 5 MG | $126.00 | |||
TBI3489-25MG | Yes | 25 MG | $504.00 |
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Description
Product Details
Formal Name: (3α,5α)-3-Hydroxy-pregnan-20-one
Alternate Names: (3α,5α)-Tetrahydroprogesterone; 3-OH-DHP
Molecular Formula: C21H34O2
Formula Weight: 318.49
CAS Number: 516-54-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 32 mg/ml) or in Ethanol (up to 32 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
GABA-A positive allosteric modulator
Functions
Endogenous neurosteroid which acts as a positive allosteric modulator of GABAA receptors. Recently FDA approved (Brexanolone) for postpartum depression. Inhibits TLR4 receptor activation and inflammatory signaling in macrophages and brain. Inhibits glutamate release and displays neuroprotective effects in various animal models.
Application Procedures
First dissolved in DMSO (up to 32 mg/ml) or in Ethanol (up to 32 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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