8-pCPT-2-O-Me-cAMP-AM, Epac activator (TBI2736)
$266.00
8-pCPT-2-O-Me-cAMP-AM, Epac activator
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI2736-100UG | Yes | 100 UG | $266.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: 8-(4-Chlorophenylthio)-2’-O-methyladenosine-3’,5’-cyclic monophosphate, acetoxymethyl ester
Molecular Formula: C20H21ClN5O8PS
Formula Weight: 557.91
CAS Number: 1152197-23-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Epac activator
Functions
A potent, cell-permeable Epac (exchange protein directly activated by cAMP) activator. Induces RAP1 activation and insulin secretion in pancreatic beta cell lines. Induces vascular relaxation in rat mesenteric artery. The acetoxymethyl ester confers increased cell-permeability and is cleaved by endogenous esterases to yield the active compound, 8-pCPT-2′-O-Me-cAMP. Addition to cell cultures should be done in serum-free media as esterases in serum will cleave the acetoxymethyl ester and reduce cell permeability.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 100 UG |
---|
Be the first to review “8-pCPT-2-O-Me-cAMP-AM, Epac activator (TBI2736)”
You must be logged in to post a review.
Reviews
There are no reviews yet.