2-AAPA, Glutathione & thioredoxin reductase inhibitor (TBI3238)
$108.00 – $432.00
Glutathione & thioredoxin reductase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI3238-5MG | Yes | 5 MG | $108.00 | |||
TBI3238-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: R,R′-2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)-phenylthiocarbamoylsulfanyl]propionic acid, hydrate
Molecular Formula: C18H22N4O6S4
Formula Weight: 518.70
CAS Number: 1133387-90-2
Purity: >95%
Formulation: powder
Solubility: Soluble in DMSO up to 50 mg/ml
Storage: -20°C
Stability: ≥ 2 years.
Applications
Glutathione & thioredoxin reductase inhibitor
Functions
Inhibits glutathione reductase and thioredoxin reductase, IC50s=6.7 and 8.7 µM respectively, and impairs mitochondrial function. May be used to induce a cellular model of thiol oxidative stress. Enhances sensitivity of cancer cell lines to X-ray irradiation. Induces G2/M cell cycle arrest by inducing thiol oxidative stress resulting in α-tubulin S-glutathionylation-mediated microtubule depolymerization. Improves limb revascularization by glutathionylation and subsequent stabilization of HIF-1α.
Application Procedures
First dissolved in DMSO up to 50 mg/ml, then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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