N-Oleoylphenylalanine, Endogenous Uncoupler of Mitochondrial Respiration (TBI1602)

Description

Product Details

Formal Name: N-Oleoyl Phe

Alternate Names: NOPA, C18-1-Phe

Molecular Formula: C₂₇H₄₃NO₃

Formula Weight: 429.64

CAS Number: 136560-78-6

Purity: 99%

Formulation: Powder

Solubility: Soluble in DMSO (35 mg/ml)

Storage: -20°C

Stability: ≥ 1 year

Applications

Endogenous Uncoupler of Mitochondrial Respiration

Functions

N-Oleoylphenylalanine (136560-78-6) is an endogenous lipoamino acid produced via the action of a secreted enzyme PM20D1 produced by adipocytes. N-Oleoylphenylalanine binds directly to mitochondria and functions as an endogenous uncoupler of UCP1-independent respiration and is the most potent in the group of structurally different lipoamino acids evaluated. Mice treated with an analog, C18-1-Leu, were found to have improved glucose homeostasis and increased energy expenditure.

Application Procedures

First dissolved in DMSO (35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Additional information

Datasheet:

TBI1602_N-Oleoylphenylalanine_Datasheet

MSDS:

TBI1602_N-Oleoylphenylalanine_MSDS

Research use only.