Ac-LEHD-pNA, caspase-9 (TBP0143)

Description

Ac‑LEHD‑pNA is a well‑characterized colorimetric substrate designed for monitoring caspase‑9 activity. In the presence of active caspase‑9—a cysteine‑protease central to intrinsic apoptotic signaling—the enzyme specifically recognizes and cleaves the peptide bond following the LEHD sequence, liberating p‑nitroaniline (pNA). This substrate is widely used in apoptosis research to provide a straightforward, reliable measure of caspase‑9 activation via colorimetric detection.

Product Details

Formal Name: (2S,5S,8S,11S)-5-((1H-imidazol-5-yl)methyl)-8-(2-carboxyethyl)-11-isobutyl-2-(2-((4-nitrophenyl)amino)-2-oxoethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazatetradecanoic acid, 2,2,2-trifluoroacetate

Molecular Formula: C₂₉H₃₈N₈O₁₁ • XCF₃COOH

Formula Weight: 674.7

CAS Number: 921771-40-6

Purity: ≥95%

Formulation: powder

Storage: -20°C

Stability: ≥ 4 years

Solubility: Water: 1 mg/ml

Research use only.

Additional information

Datasheet:

TBP0143-Ac-LEHD-pNA_datasheet

MSDS:

TBP0143_Ac-LEHD-pNA_MSDS

Research use only.