TPCK, Serine protease inhibitor (TBI2290)

Description

Product Details

Formal Name: N-p-Tosyl-L-phenylalanine chloromethyl ketone

Molecular Formula: C₁₇H₁₈ClNO₃S

Formula Weight: 351.80

CAS Number: 402-71-1

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 10 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

 

Applications

Serine protease inhibitor

 

Functions

TPCK is an irreversible inhibitor of the serine protease chymotrypsin. It also inhibits certain cysteine proteases (bromelain, ficin, papain).  TPCK inhibited (IC50 = 5 µM) the mitogen-induced activation of pp70s6k, a mitogen-regulated serine/threonine kinase involved in the G1 to S phase transition of the cell cycle.

 

Application Procedures

First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.

Additional information

SIZE (mg)	2 G, 500 MG

TBI2290_TPCK