Irinotecan HCl, Topoisomerase I inhibitor (TBI2146)
$108.00 – $432.00
Topoisomerase I inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2146-50MG | Yes | 50 MG | $108.00 | |||
TBI2146-250MG | Yes | 250 MG | $432.00 |
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Description
Product Details
Formal Name: (S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4’-bipiperidine]-1’-carboxylate hydrochloride
Molecular Formula: C33H38N4O6 ∙ HCl ∙ 3H20
Formula Weight: 586.69 ∙ 36.46 ∙ 54.05
CAS Number: 100286-90-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Topoisomerase I inhibitor
Functions
Irinotecan is a semi-synthetic derivative of camptothecin that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I. Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).
Application Procedures
First dissolved in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml), then diluted to aqueous buffer. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 250 MG, 50 MG |
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