Leflunomide, DHODH inhibitor; immunosuppresant (TBI2369)
$72.00 – $288.00
DHODH inhibitor; immunosuppresant
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2369-50MG | Yes | 50 MG | $72.00 | |||
TBI2369-250MG | Yes | 250 MG | $288.00 |
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Description
Product Details
Formal Name: 5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
Alternate Names: RS-34821
Molecular Formula: C12H9F3N2O2
Formula Weight: 270.21
CAS Number: 75706-12-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 25 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
DHODH inhibitor; immunosuppresant
Functions
A pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug). Displays immunomodulatory activity inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH). Although the molecule directly responsible for DHODH is actually A77 1726, a metabolite of Leflunomide.
Rescues mice from acetaminophen-induced liver injury.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 250 MG, 50 MG |
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