Tranylcypromine hemisulfate (±), Demethylase inhibitor (TBI4535)
$72.00 – $270.00
Demethylase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4535-50MG | Yes | 50 MG | $72.00 | |||
TBI4535-250MG | Yes | 250 MG | $270.00 |
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Description
Product Details
Formal Name: Trans (±)-2-phenylcyclopropanamine, hemisulfate salt
Alternate Names: 2-PCPA; SKF-385
Molecular Formula: C9H11N ∙ 1/2(H2SO4)
Formula Weight: 182.23
CAS Number: 13492-01-8
Purity: >98%
Formulation: powder
Solubility: Soluble in Water (up to 25 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Demethylase inhibitor
Functions
Irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) IC50 < 2 µM. Tranylcypromine treatment of P19 embryonal carcinoma cells resulted in global increase of H3K4 methylation along with transcriptional derepression of two BHC110 target genes, Egr1 and Oct4. When combined with CHIR99021, induces the generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Reduces proliferation, cell cycle progression and invasiveness of endometriotic stromal cells. Upregulates CD86 expression in THP1 cells. Monoamine oxidase inhibitor. Cell permeable and active in vivo.
Application Procedures
First dissolved in Water (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in distilled water may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 250 MG, 50 MG |
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