Candesartan, Angiotensin AT1 receptor antagonist (TBI2049)
$72.00 – $216.00
Angiotensin AT1 receptor antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2049-50MG | Yes | 50 MG | $72.00 | |||
TBI2049-250MG | Yes | 250 MG | $216.00 |
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Description
Product Details
Formal Name: 2-Ethoxy-1-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid
Alternate Names: CV-11974
Molecular Formula: C24H20N6O3
Formula Weight: 400.45
CAS Number: 139481-59-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 40 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Angiotensin AT1 receptor antagonist
Functions
Angiotensin II receptor I (AT1) antagonist, IC50s=1.12 and 2.86 nM for bovine adrenal cortex and rabbit aorta respectively. Selectively inhibits angiotensin II-induced contraction of rabbit aortic strips with no effect on contraction induced by other agents such as norepinephrine, KCl, serotonin, PGF2α or endothelin. Prevents astrocyte and microglial activation and neuroinflammation and improves hippocampal neurogenesis. Attenuates angiogenesis in hepatocellular carcinoma. Clinically useful antihypertensive agent. Ameliorates brain inflammation associated with Alzheimer’s disease. Active in vivo and orally active.
Application Procedures
First dissolved in DMSO (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 250 MG, 50 MG |
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