Ko-143, BCRP inhibitor (TBI1074)
$180.00 – $810.00
BCRP inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1074-5MG | Yes | 5 MG | $180.00 | |||
TBI1074-25MG | Yes | 25 MG | $810.00 |
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Description
Product Details
Formal Name: (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1′,2′:1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester
Molecular Formula: C26H36N3O5
Formula Weight: 470.59
CAS Number: 461054-93-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 50 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
BCRP inhibitor
Functions
A potent and selective inhibitor of the breast cancer resistance protein multidrug transporter (BCRP/ABCG2). Reverses resistance of MTX and topotecan at 25 nM in human and mouse cell lines. Also inhibits ABCB1 and ABCC1 at concentrations >1 μM. Restores the sensitivity of triple negative breast cancer cells to photodynamic therapy. Prevents the export of the FAAH inhibitor URB937 from the CNS. Forces prostate stem cells to undergo and AR-modulated differentiation to an androgen deprivation therapy-sensitive luminal phenotype. Active in vivo.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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