Spautin-1, USP10&13 inhibitor; autophagy inhibitor (TBI1367)
$117.00 – $432.00
USP10&13 inhibitor; autophagy inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1367-5MG | Yes | 5 MG | $117.00 | |||
TBI1367-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: 6-Fluoro-N[(4-fluorophenyl)methyl]-4-quinazolinamine
Molecular Formula: C15H11F2N3
Formula Weight: 271.27
CAS Number: 122888-28-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
Storage: -20°C
Stability: ≥ 1 year.
Applications
USP10&13 inhibitor; autophagy inhibitor
Functions
A specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1 subunit of Vps34 complexes. Deranges dengue virion maturation. Inhibits autophagy in a Beclin-1 independent manner in primary epithelial ovarian cancer cells. Selectively induces cell death of mutant p53-expressing cancer cell lines under confluency. Cell permeable.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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