Tafamidis, Transthyretin stabilizer (TBI3743)
$108.00 – $360.00
Transthyretin stabilizer
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3743-5MG | Yes | 5 MG | $108.00 | |||
TBI3743-25MG | Yes | 25 MG | $360.00 |
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Description
Product Details
Formal Name: 2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic acid
Alternate Names: PF-06291826
Molecular Formula: C14H7Cl2NO3
Formula Weight: 308.10
CAS Number: 594839-88-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO up to 20 mg/ml
Storage: -20°C
Stability: ≥ 2 years.
Applications
Transthyretin stabilizer
Functions
Potent and selective transthyretin (TTR) kinetic stabilizer. It binds selectively and with negative cooperativity to the two normally unoccupied thyroxine binding sites of the TTR tetramer (Kd = ~2 and ~200 nM). Stabilizes wild-type and mutant TTR under varying conditions in vitro (EC50=2.7-3.2 μM). Clinically useful for the treatment of familial amyloid polyneuropathy and TTR-related cardiomyopathy.
Application Procedures
First dissolved in DMSO up to 20 mg/ml, then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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