DMXAA, STING activator (mouse); Tumor vascular disrupting agent (TBI2676)
$108.00 – $432.00
STING activator (mouse); Tumor vascular disrupting agent
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI2676-5MG | Yes | 5 MG | $108.00 | |||
TBI2676-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: 5,6-Dimethylxanthenone-4-acetic acid
Alternate Names: ASA404; Vadimezan
Molecular Formula: C17H14O4
Formula Weight: 282.29
CAS Number: 117570-53-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 5 mg/ml) or in DMF (up to 14 mg/ml with warming)
Storage: RT
Stability: ≥ 1 year.
Applications
STING activator (mouse); Tumor vascular disrupting agent
Functions
STING (Stimulator of Interferon Genes) agonist selective for mouse STING. Intratumoral administration of DMXAA resulted in tumor regression and complete rejection in mouse xenografts. Tumor regression induced by DMXAA results from a cascade of cellular events which include disruption of tumor vasculature followed by the release of chemokines which trigger the recruitment of immune cells. DMXAA induced expression of IFN-β resulting in a striking expansion of leukemia-specific T cells extending survival in two acute myeloid leukemia models.
Application Procedures
First dissolved in DMSO (up to 5 mg/ml) or in DMF (up to 14 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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