Eltrombopag, Small molecule thrombopoietin agonist (TBI3768)
$99.00 – $297.00
Small molecule thrombopoietin agonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI3768-5MG | Yes | 5 MG | $99.00 | |||
TBI3768-25MG | Yes | 25 MG | $297.00 |
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Description
Product Details
Formal Name: 3’-[2-[(2Z)-1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2’-hydroxy-[1,1’-biphenyl]-3-carboxylic acid
Alternate Names: SB-497115
Molecular Formula: C25H22N4O4
Formula Weight: 442.47
CAS Number: 496775-61-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 55 mg/ml) or in Ethanol (up to 14 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Small molecule thrombopoietin agonist
Functions
A novel, orally active, small molecule human thrombopoietin receptor (TPO-R) agonist, EC50=0.27 μM. Maintains human hematopoietic stem and progenitor cells under inflammatory conditions. Promotes DNA repair in human hematopoietic stem and progenitor cells. Acts as a powerful chelator of cellular and extracellular iron(III). Stimulates hematopoietic stem cells via a TPO-R-independent mechanism involving iron chelation.
Application Procedures
First dissolved in DMSO (up to 55 mg/ml) or in Ethanol (up to 14 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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