PB28, Sigma-2 agonist (TBI4665)
$63.00 – $252.00
Sigma-2 agonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4665-5MG | Yes | 5 MG | $63.00 | |||
TBI4665-25MG | Yes | 25 MG | $252.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: 1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine, dihydrochloride
Molecular Formula: C24H38N2O·2HCl
Formula Weight: 443.50
CAS Number: 172907-03-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Water (up to 5 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Sigma-2 agonist
Functions
Potent, high affinity (Ki = 0.34 nM) σ2 agonist. Its antiproliferative (EC50 ~ 0.4 µM) and cytotoxic (EC50 ~ 12 µM) effects on glioma and neuroblastoma cell lines indicate it is also a σ1 antagonist. PB28 also inhibited cell growth in MCF7 breast cancer lines, and was strongly synergistic with doxorubicin. PB28 potently inhibited Kv2.1 channels in a σ-independent manner. Recently, PB28 showed potent (IC50 = 280 nM; 20-fold more than hydroxychloroquine) anti-SARS-CoV2 activity, without cardiac side effects.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Water (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “PB28, Sigma-2 agonist (TBI4665)”
You must be logged in to post a review.
Reviews
There are no reviews yet.