ML-239, Selective cancer stem cell killer (TBI1417)
$117.00 – $468.00
Selective cancer stem cell killer
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1417-5MG | Yes | 5 MG | $117.00 | |||
TBI1417-25MG | Yes | 25 MG | $468.00 |
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Description
Product Details
Formal Name: (2,4,6-Trichlorophenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide
Molecular Formula: C13H10Cl3N3O2
Formula Weight: 346.60
CAS Number: 1378872-36-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml), in DMF (up to 25 mg/ml), or in Ethanol (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Selective cancer stem cell killer
Functions
A novel inhibitor of the growth and proliferation of breast cancer stem cells (CSC) discovered in a phenotypic screen employing CSC-like cells produced by inducing human breast epithelial cells into an epithelial-to-mesenchymal transdifferentiated state (HMLE_sh_ECad). ML239 displayed an IC50=1.18 μM against HMLE_sh_ECad and demonstrated a >23-fold selectivity over control cells. It was also toxic to two other CSC-like lines. Gene expression studies showed altered gene expression in the NFκB pathway and support activation of fatty acid desaturase 2 (FADS2) as a potential mechanism of action for ML239.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), in DMF (up to 25 mg/ml), or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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