GRL-0617, SARS-CoV-2 papain-like protease (PLpro, Nsp3) inhibitor (TBI4965)
$135.00 – $450.00
SARS-CoV-2 papain-like protease (PLpro, Nsp3) inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4965-5MG | Yes | 5 MG | $135.00 | |||
TBI4965-25MG | Yes | 25 MG | $450.00 |
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Description
Product Details
Formal Name: 5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide
Molecular Formula: C20H20N2O
Formula Weight: 304.40
CAS Number: 1093070-16-6
Purity: >99%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml) or Ethanol (up to 15 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
SARS-CoV-2 papain-like protease (PLpro, Nsp3) inhibitor
Functions
GRL-0617 is a noncovalent inhibitor of the protease PLpro (papain-like protease; Nsp3) encoded by coronaviruses SARS-CoV (EC50 = 15 µM in Vero cells) and COVID-19 SARS-CoV-2 (EC50 = 28 µM in Vero cells), with no cytotoxicity. Although it was identified in a screen using a fluorescent peptide substrate comprising the 5 C-terminal residues of ubiquitin, it does not inhibit human deubiquitinating enzymes HAUSP, USP18, UCH-L1, UCH-L3, or PLP2.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml) or Ethanol (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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