SSAA09E1, SARS-CoV viral entry inhibitor (TBI5075)
$108.00 – $351.00
SARS-CoV viral entry inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI5075-5MG | Yes | 5 MG | $108.00 | |||
TBI5075-25MG | Yes | 25 MG | $351.00 |
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Description
Product Details
Formal Name: [(Z)-1-thiophen-2-ylethylideneamino]thiourea
Molecular Formula: C7H9N3S2
Formula Weight: 199.30
CAS Number: 433212-75-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 100 mg/ml); or Ethanol (10 mg/ml, warm)
Storage: -20°C
Stability: ≥ 2 years.
Applications
SARS-CoV viral entry inhibitor
Functions
An inhibitor of SARS coronavirus (SARS-CoV) replication by blocking viral entry (EC50=6.7µM). SSAA09E1 was discovered by screening a chemical library for blocking of entry of HIV-1 pseudotyped with SARS-CoV surface glycoprotein S. The compound acts via inhibition of cathepsin L (IC50=5.33 µM), a host protease required for processing of SARS-S during viral entry. Cathepsin B is not inhibited. The compound was also shown to inhibit tyrosinase (IC50=0.14 µM).
Application Procedures
First dissolved in DMSO (up to at least 100 mg/ml); or Ethanol (10 mg/ml, warm), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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