Homoharringtonine, Protein synthesis inhibitor (TBI3033)
$117.00 – $396.00
Protein synthesis inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3033-5MG | Yes | 5 MG | $117.00 | |||
TBI3033-25MG | Yes | 25 MG | $396.00 |
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Description
Product Details
Formal Name: Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
Alternate Names: HHT; NSC 141633; Omacetaxine mepesuccinate
Molecular Formula: C29H39NO9
Formula Weight: 545.60
CAS Number: 26833-87-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 75 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Protein synthesis inhibitor
Functions
Homoharringtonine is a plant alkaloid, originally isolated from the Hainan plum yew, that binds to the large ribosomal subunit A-site, competing with aminoacyl-tRNA amino acid side chains, thereby inhibiting the initial elongation step of protein synthesis. It also binds to transcription factors NKRF (NF-κB repressing factor) and SP1, down-regulating the Myc pathway. Dramatically decreases global DNA 5-hydroxymethylcytosine levels via the SP1/TET1 axis. Induces apoptosis in tyrosine kinase inhibitor-resistant NSCLC cells, and is a clinically useful agent for CML and AML.
Application Procedures
First dissolved in DMSO (up to 75 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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