Elafibranor, PPARalpha/delta agonist (TBI3901)
$117.00 – $423.00
PPARalpha/delta agonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI3901-5MG | Yes | 5 MG | $117.00 | |||
TBI3901-25MG | Yes | 25 MG | $423.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: 2-[2,6-Dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenoxy]-2-methylpropanoic acid
Alternate Names: GFT505
Molecular Formula: C22H24O4S
Formula Weight: 384.50
CAS Number: 923978-27-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
PPARalpha/delta agonist
Functions
Elafibranor is a dual PPARalpha/delta agonist (EC50 PPARalpha = 10-20 nM; PPARdelta = 100-150 nM). It was able to decrease plasma triglycerides levels, increase HDL cholesterol levels in human studies, and improve hepatic and peripheral insulin sensitivity. Elafibranor’s antidiabetic effects in db/db were without the adverse cardiac effects seen in PPARgamma agonism. Elafibranor has also been shown to have therapeutic promise in the treatment of nonalcoholic steatohepatitis (NASH).
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “Elafibranor, PPARalpha/delta agonist (TBI3901)”
You must be logged in to post a review.
Reviews
There are no reviews yet.