EPZ015666, Potent and selective PRMT5 inhibitor (TBI4031)
$162.00 – $585.00
Potent and selective PRMT5 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4031-5MG | Yes | 5 MG | $162.00 | |||
TBI4031-25MG | Yes | 25 MG | $585.00 |
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Description
Product Details
Formal Name: (S)-N-(3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
Molecular Formula: C20H25N5O3
Formula Weight: 383.44
CAS Number: 1616391-65-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Potent and selective PRMT5 inhibitor
Functions
Potent (IC50 = 22 nM) and selective inhibitor of arginine methyltransferase 5 (PRMT5). PRMT5 dimethylates Myc, and its inhibition by EPZ015666 suppresses cell growth and induces apoptosis and/or cell cycle arrest in medulloblastoma and retinoblastoma cells. It also sensitizes glioblastoma cells to mTOR inhibitor PP2426.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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