NDI-091143, Potent allosteric ATP-citrate lyase inhibitor (TBI4841)
$108.00 – $396.00
Potent allosteric ATP-citrate lyase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4841-5MG | Yes | 5 MG | $108.00 | |||
TBI4841-25MG | Yes | 25 MG | $396.00 |
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Description
Product Details
Formal Name: Methyl 3-Chloro-5-[(2,4-difluoro-5-phenylphenyl)sulfamoyl]-4-hydroxybenzoate
Molecular Formula: C20H14ClF2NO5S
Formula Weight: 453.84
CAS Number: 2375840-87-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Potent allosteric ATP-citrate lyase inhibitor
Functions
Potent (IC50 = 2.1 nM ADP-Glo assay; 4.8 nM Oxaloacetate coupled enzyme assay) allosteric inhibitor of ATP-citrate lyase. NDI-091143 suppressed growth and clonogenic ability in thyroid cancer cell lines FTC-133 and 8505C. It also synergistically potentiated the cytotoxicity of sorafenib.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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