FSC-231, PICK1 PDZ domain inhibitor (TBI1406)
$108.00 – $432.00
PICK1 PDZ domain inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1406-5MG | Yes | 5 MG | $108.00 | |||
TBI1406-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: (E)-Ethyl-2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate
Molecular Formula: C13H10Cl2N2O3
Formula Weight: 313.14
CAS Number: N/A
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 35 mg/ml with warming) or in Ethanol (up to 18 mg/ml with warming)
Storage: RT
Stability: ≥ 1 year.
Applications
PICK1 PDZ domain inhibitor
Functions
The first small-molecule inhibitor of the PDZ domain in protein interacting with C kinase 1 (PICK1). Binds to PICK1 PDZ domain with affinity similar to that of the endogenous peptide ligands (Ki~10.1 µM). Does not bind to PDZ domains of postsynaptic density protein 95 (PSD-95) nor glutamate receptor interacting protein 1 (GRIP1). Pretreatment of cultured hippocampal neurons inhibits coimmunoprecipitation of the AMPA receptor GluR2 subunit with PICK1. FSC231 accelerated recycling of fluorophore-tagged GluR2 in hippocampal neurons after internalization in response to NMDA receptor activation. Blocks the expression of both long-term depression and long-term potentiation. Attenuates cocaine seeking in a rodent model. Blocks PICK1-induced anti-inflammatory effect in acute liver injury.
Application Procedures
First dissolved in DMSO (up to 35 mg/ml with warming) or in Ethanol (up to 18 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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