Buparlisib, PI3K inhibitor (pan-Class I) (TBI4325)
$126.00 – $477.00
PI3K inhibitor (pan-Class I)
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4325-5MG | Yes | 5 MG | $126.00 | |||
TBI4325-25MG | Yes | 25 MG | $477.00 |
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Description
Product Details
Formal Name: 5-(2,6-Dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridine-2-amine
Alternate Names: NVP-BKM120; BKM-120
Molecular Formula: C18H21F3N6O2
Formula Weight: 410.40
CAS Number: 944396-07-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 15 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
PI3K inhibitor (pan-Class I)
Functions
Inhibits Class I PI3K isoforms [e.g. p110α (IC50 = 52 nM), p110δ (IC50 = 116 nM] but not Class III or IV [e.g. Vps34, mTOR, PI4Kβ]. Blocks or pauses glioma cell cycle at G2/M depending on p53 status. At 5 mg/kg, efficiently inhibits phosphorylation of PI3K target AKT Ser473 in mouse brains. Augments chaperone-mediated autophagy (CMA) in lysosomes isolated from mouse liver.
Application Procedures
First dissolved in DMSO (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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