ZSTK474, PI 3-Kinase inhibitor (TBI2180)
$86.00 – $252.00
PI 3-Kinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2180-5MG | Yes | 5 MG | $86.00 | |||
TBI2180-25MG | Yes | 25 MG | $252.00 |
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Description
Product Details
Formal Name: 2-(2-Difluoromethylbenzoimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine
Molecular Formula: C19H21F2N7O2
Formula Weight: 417.41
CAS Number: 475110-96-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 2.5 mg/ml with warming).
Storage: -20°C
Stability: ≥ 2 years.
Applications
PI 3-Kinase inhibitor
Functions
Novel Class I phosphatidylinositol 3-kinase (PI3K) inhibitor. ZSTK474 is an ATP-competitive inhibitor of all four Class I PI3K isoforms. However, it inhibits PI3Kδ most potently, with a Ki of 1.8 nM, while inhibiting the α, β and γ isoforms at slightly higher concentrations (6.7 nM, 10.4 nM and 11.7 nM, respectively). Displays potent antitumor activity against human cancer xenografts (A549, PC-3 and WiDr) when administered to mice. It displays potent anti-inflammatory activity via modulation of human CD14+ monocyte-derived dendritic cell functions and suppresses experimental autoimmune encephalomyelitis. Ameliorates the progression of adjuvant-induced arthritis in a rat model.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml) or in Ethanol (up to 2.5 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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