GSK2656157, PERK inhibitor (TBI4855)
$72.00 – $288.00
PERK inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4855-5MG | Yes | 5 MG | $72.00 | |||
TBI4855-25MG | Yes | 25 MG | $288.00 |
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Description
Product Details
Formal Name: 1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydroindol-1-yl]-2-(6-methylpyridin-2-yl)ethanone
Molecular Formula: C23H21FN6O
Formula Weight: 416.50
CAS Number: 1337532-29-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 10 mg/ml with warming)
Storage: -20°C
Stability: ≥ 1 year.
Applications
PERK inhibitor
Functions
Potent (IC50 = 0.9 nM) and selective (over 300 kinases) inhibitor of protein kinase RNA-like endoplasmic reticulum kinase (PERK). Inhibited growth of multiple human tumor xenografts in mice. Also potently inhibits RIPK1 (IC50 = 69 nM) and TNF-mediated RIPK1 kinase-dependent cell death in MEFs. Prevented the loss of dendritic spines and rescued memory deficits after traumatic brain injury. Enhances glucose-stimulated insulin secretion in a mouse model of type 2 diabetes mellitus.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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