GPI-16552, PARG inhibitor (TBI1502)
$108.00 – $432.00
GPI-16552, PARG inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1502-5MG | Yes | 5 MG | $108.00 | |||
TBI1502-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: N-bis-(3-Phenyl-propyl)-9-oxo-fluorene-2,7-diamide
Molecular Formula: C33H30N2O3
Formula Weight: 502.60
CAS Number: 443794-40-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in DMF (up to 25 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
PARG inhibitor
Functions
A novel potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG), IC50=1.7 μM. Pre or post ischemia treatment (40 mg/kg) with GPI-16552 reduces brain infarct volumes in a rat model of cerebral ischemia. It modulates the inflammatory response to ischemia/reperfusion in a rat splanchnic artery occlusion model and reduces the degree of spinal cord inflammation and tissue injury after experimental spinal cord trauma. Synergizes with temozolomide in decreasing melanoma cell invasion and metastatic spreading in mice injected with B16 melanoma cells.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in DMF (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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