Brigatinib, pan-ALK inhibitor (TBI5034)
$90.00 – $288.00
pan-ALK inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI5034-5MG | Yes | 5 MG | $90.00 | |||
TBI5034-25MG | Yes | 25 MG | $288.00 |
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Description
Product Details
Formal Name: 5-Chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4-pyrimidinediamine
Alternate Names: AP26113
Molecular Formula: C29H39ClN7O2P
Formula Weight: 584.10
CAS Number: 1197953-54-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 1 mg/ml, warm)
Storage: -20°C
Stability: ≥ 2 years.
Applications
pan-ALK inhibitor
Functions
A potent and selective pan-ALK inhibitor IC50=0.6 nM. Cells with ALK mutation L1196Q and the double mutation I1171S + G1269 remain sensitive to brigatinib. Clinically useful in non-small cell lung cancer.
Application Procedures
First dissolved in DMSO (up to 1 mg/ml, warm), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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