Isohelenin, NFkB inhibitor (TBI5393)
$90.00 – $324.00
NFkB inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5393-5MG | Yes | 5 MG | $90.00 | |||
TBI5393-25MG | Yes | 25 MG | $324.00 |
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Description
Product Details
Formal Name: (3aR,8aR,9aR)-8a-methyl-3,5-dimethylenedecahydronaphtho[2,3-b]furan-2(3H)-one
Alternate Names: Isoalantolactone
Molecular Formula: C15H20O2
Formula Weight: 232.30
CAS Number: 470-17-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (50 mg/ml); or Ethanol (30 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
NFkB inhibitor
Functions
A sesquiterpene lactone isolated from Mexican Indian medicinal plants known to have anti-inflammatory properties. A potent inhibitor of NFkB (complete inhibition at 5 µM) acting via inhibition of IKKß6. Isohelenin-mediated NFkB inhibition suppresses IL-8 expression, iNOS expression and RANTES biosynthesis. Displays protective effects in endotoxic shock in rodent models. Induces apoptosis in glioma cells.
Application Procedures
First dissolved in DMSO (50 mg/ml); or Ethanol (30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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