Phosphoramidon, Neutral endopeptidase inhibitor (TBI2548)
$180.00 – $720.00
Neutral endopeptidase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2548-5MG | Yes | 5 MG | $180.00 | |||
TBI2548-25MG | Yes | 25 MG | $720.00 |
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Description
Product Details
Formal Name: N-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan • 2Na
Molecular Formula: C23H32N3O10P·2Na
Formula Weight: 587.47
CAS Number: 119942-99-3
Purity: >95%
Formulation: powder
Solubility: Soluble in DMSO, methanol and water
Storage: -20°C
Stability: ≥ 2 years.
Applications
Neutral endopeptidase inhibitor
Functions
Inhibits neutral endopeptidase 24.11 (NEP; Neprilysin; EC 3.4.24.11), Ki=2 nM. Also inhibits neprilysin 2 (Ki~2 nM). Also inhibits endothelin-converting enzyme (IC50 = 0.68 μM). Induces a dramatic increase in amyloid-beta levels in rodents.
Application Procedures
First dissolved in DMSO, methanol and water, then diluted to aqueous buffer. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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