P7C3, NAMPT activator; Neuroprotective (TBI1150)
$108.00 – $432.00
NAMPT activator; Neuroprotective
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1150-5MG | Yes | 5 MG | $108.00 | |||
TBI1150-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: 1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol
Molecular Formula: C21H18Br2N2O
Formula Weight: 474.20
CAS Number: 301353-96-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
NAMPT activator; Neuroprotective
Functions
P7C3 exerts proneurogenic activity by protecting newborn neurons from apoptosis. Prolonged administration to aged rats impedes neuronal death and preserves cognitive capacity. Delays disease progression in G93A-SOD2 mutant mouse model of amyotrophic lateral sclerosis. Blocks MPTP-mediated cell death of dopaminergic neurons in the substantia nigra of adult mice, a model of Parkinson disease. Restores hippocampal neurogenesis in a mouse model of Down Syndrome. The mechanism of action involves activation of nicotinamide phosphoribosyltransferase (NAMPT) with concomitant increase of intracellular levels of NAD. Active in vivo.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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