Torin 1, mTOR inhibitor (TBI3013)
$126.00 – $504.00
mTOR activator
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3013-5MG | Yes | 5 MG | $126.00 | |||
TBI3013-25MG | Yes | 25 MG | $504.00 |
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Description
Product Details
Formal Name: 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
Molecular Formula: C35H28F3N5O2
Formula Weight: 607.60
CAS Number: 1222998-36-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 8 mg/ml with warming)
Storage: -20°C
Stability: ≥ 2 years.
Applications
mTOR inhibitor
Functions
Potent and selective ATP-competitive mTOR inhibitor, IC50=2 and 10 nM for mTORC1 and mTORC2 respectively. Active in vivo at inhibition of mTOR-mediated effects in mice (20 mg/kg). Induces autophagy. Torin 1-mediated enhancement of TFEB-mediated autophagy alleviates neuronal death in oxidative stress-induced disease models. Downregulates NGF expression in RSC96 cells.
Application Procedures
First dissolved in DMSO (up to 8 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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