TH588, MTH1/NUDT1 inhibitor (TBI4602)
$99.00 – $297.00
MTH1/NUDT1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4602-5MG | Yes | 5 MG | $99.00 | |||
TBI4602-25MG | Yes | 25 MG | $297.00 |
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Description
Product Details
Formal Name: N4-Cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine hydrochloride
Molecular Formula: C13H12Cl2N4·HCl
Formula Weight: 331.63
CAS Number: 1609960-31-7 (free base)
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 5 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
MTH1/NUDT1 inhibitor
Functions
TH588 is a first-in-class nudix hydrolase family inhibitor. MTH1/NUDT1 is a family member that “sanitizes” oxidized deoxynucleotide triphosphates (dNTP) preventing their incorporation into DNA and thus avoiding DNA damage and cell death. TH588 inhibits MTH1/NUDT1 (IC50 = 5 nM) leading to cell death in several cancer cell lines while not affecting normal cells. Active in vitro and in vivo. Recent evidence has raised doubts about the cancer-killing ability of MTH1 inhibition.
Application Procedures
First dissolved in DMSO (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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