PFI-2 HCl (R-), Methyltransferase SETD7 inhibitor (TBI4033)
$178.00 – $675.00
Methyltransferase SETD7 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4033-5MG | Yes | 5 MG | $178.00 | |||
TBI4033-25MG | Yes | 25 MG | $675.00 |
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Description
Product Details
Formal Name: (1R)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl-1,2,3,4-tetrahydro-6-isoquinolinesulfonamide hydrochloride
Molecular Formula: C23H25F4N3O3S HCl
Formula Weight: 535.98
CAS Number: 1627607-87-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Methyltransferase SETD7 inhibitor
Functions
(R)-PFI-2 (1627607-87-7) is a potent (IC50 = 2nM) and selective SAM-dependent inhibitor of the lysine methyltransferase SETD7. It alters Hippo pathway signaling in MCF7 cells by altering YAP nuclear localization in a SETD7-dependent manner.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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