JPH203, LAT1 inhibitor (TBI4463)
$153.00 – $531.00
LAT1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4463-5MG | Yes | 5 MG | $153.00 | |||
TBI4463-25MG | Yes | 25 MG | $531.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: (2S)-2-Amino-3-[4-[(5-amino-2-phenyl-1,3-benzoxazol-7-yl)methoxy]-3,5-dichlorophenyl]propanoic acid, dihydrochloride
Alternate Names: KYT-0353; Nanvuralant
Molecular Formula: C23H19Cl2N3O4·2HCl
Formula Weight: 545.24
CAS Number: 1597402-27-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
LAT1 inhibitor
Functions
Selective L-type amino acid transporter 1 inhibitor (LAT1 or SLC7A5; IC50 = 140 nM for 14C-leucine uptake in S2-hLAT1 cells, and 60 nM for HT29 human colon adenocarcinoma cells: growth inhibition IC50’s = 16.4 µM and 4.1 µM respectively for S2 and HT29 cells). Also active in HT-29 mouse xenograft models. JPH203 is active in a variety of cancer models and has progressed to clinical trials. It sensitized A549 and MIA Paca-2 cells to radiation by enhancing cellular senescence via mTOR downregulation and sensitized EGFR-expressing cancer cell lines to gefitinib therapy. JPH203 treatment of non-small cell lung cancer cells led to downregulation of PD-L1 suggesting that LAT1 inhibition may help overcome the immune suppressive tumor microenvironment.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “JPH203, LAT1 inhibitor (TBI4463)”
You must be logged in to post a review.
Reviews
There are no reviews yet.