Cabozantinib, Met and VEGFR2 inhibitor (TBI3231)
$126.00 – $414.00
Met and VEGFR2 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3231-5MG | Yes | 5 MG | $126.00 | |||
TBI3231-25MG | Yes | 25 MG | $414.00 |
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Description
Product Details
Formal Name: N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Alternate Names: XL-184; BMS-907351
Molecular Formula: C28H24FN3O5
Formula Weight: 501.51
CAS Number: 849217-68-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO.
Storage: -20°C
Stability: ≥ 1 year.
Applications
Met and VEGFR2 inhibitor
Functions
Novel inhibitor of c-met and VEGFR2 kinase activity, IC50=3.5 nm and 35 pM respectively. Inhibits MET-activating kinase domain mutations Y1248H, D1246N or K1262R, IC50=3.8, 11.8 and 14.6 nM respectively. In cellular assays it inhibits the following kinases: MET, VEGF2, KIT, FLT3 and AXL, IC50=7.8, 1.9, 5.0, 7.5 and 42 μM respectively. Eliminated approximately 80% of vasculature in spontaneous pancreatic islet tumors over 7 days in a mouse model. Clinically useful anticancer agent.
Application Procedures
First dissolved in DMSO, then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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