AS-8351, KDM5B histone demethylase inhibitor (TBI1597)

Description

Product Details

Formal Name: 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone

Alternate Names: NSC-51355

Molecular Formula: C₁₇H₁₃N₃O₂

Formula Weight: 291.30

CAS Number: 796-42-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 45 mg/ml), in DMF (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming)

Storage: -20°C

Stability: ≥ 2 years.

 

Applications

KDM5B histone demethylase inhibitor

 

Functions

AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts. It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.

 

Application Procedures

First dissolved in DMSO (up to 45 mg/ml), in DMF (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Additional information

SIZE (mg)	25 MG, 5 MG

Datasheet:

TBI1597_AS-8351

MSDS:

TBI1597_AS-8351_MSDS_2024