PBIT, JARID1 inhibitor (TBI1595)
$112.00 – $432.00
JARID1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1595-5MG | Yes | 5 MG | $112.00 | |||
TBI1595-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: 2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one
Molecular Formula: C14H11NOS
Formula Weight: 241.31
CAS Number: 2514-30-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 24 mg/ml) or in Ethanol (up to 5 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
JARID1 inhibitor
Functions
The JARID1 (Jumonji AT-Rich Interactive Domain 1) family of lysine demethylases demethylates the trimethylated lysine 27 in histone H3 (H3K4me3). PBIT is a potent and selective inhibitor of JARID1 (IC50 = 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Treatment of cells with PBIT inhibits the demethylation of H3K4me3. It inhibits proliferation of breast cancer cell lines expressing high levels of JARID1B1.
Application Procedures
First dissolved in DMSO (up to 24 mg/ml) or in Ethanol (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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