AG-490, JAK2 inhibitor (TBI1091)
$90.00 – $270.00
JAK2 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI1091-5MG | Yes | 5 MG | $90.00 | |||
TBI1091-25MG | Yes | 25 MG | $270.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: (E)-2-Cyano-3-(3,4-dihydrophenyl)-N¬-(phenylmethyl)-2-propenamide
Molecular Formula: C17H14N2O3
Formula Weight: 294.31
CAS Number: 133550-30-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml), in DMF (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
JAK2 inhibitor
Functions
A potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. Reduces liver injury in LPS-induced shock. A useful tool for exploring the role of JAK2/STAT3 pathway in physiologic processes.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), in DMF (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “AG-490, JAK2 inhibitor (TBI1091)”
You must be logged in to post a review.
Reviews
There are no reviews yet.