Telaprevir, Hepatitis C protease inhibitor (TBI4929)
$90.00 – $270.00
Hepatitis C protease inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4929-5MG | Yes | 5 MG | $90.00 | |||
TBI4929-25MG | Yes | 25 MG | $270.00 |
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Description
Product Details
Formal Name: (3S,3aS,6aR)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
Alternate Names: VX-950
Molecular Formula: C36H53N7O6
Formula Weight: 679.86
CAS Number: 402957-28-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Hepatitis C protease inhibitor
Functions
Hepatitis C NS3/4A protease inhibitor that is in clinical use for genotype 1 infections (IC50 = 354 nM genotype 1b replicon cells; IC50 = 280 nM human fetal hepatocytes infected with genotype 1a HCV-positive patient sera). It has been shown to inhibit SARS-CoV2 proteases MPro (IC50 = 15 µM) and 3CLPro (IC50 = 56 µM). Telaprevir is also an allosteric inhibitor of DnaK, the bacterial homolog of Hsp70. It enhanced the efficacy of aminoglycoside antibiotics and reduced resistance to the tuberculosis drug rifampin.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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