Picropodophyllotoxin, IGF1R inhibitor (TBI2189)
$144.00 – $576.00
IGF1R inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2189-5MG | Yes | 5 MG | $144.00 | |||
TBI2189-25MG | Yes | 25 MG | $576.00 |
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Description
Product Details
Formal Name: (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro¬-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3′,4′:6,7¬]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Molecular Formula: C22H22O8
Formula Weight: 414.42
CAS Number: 477-47-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 40 mg/ml).
Storage: RT
Stability: ≥ 1 year.
Applications
IGF1R inhibitor
Functions
Potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP. Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC50 ~ 1 nM. Displays antiproliferative activity in numerous tumor cell lines, IC50 = 0.05 – 15 μM. Exhibits antiangiogenic activitiy. Attenuates intimal hyperplasia after vascular injury. Active in vivo.
Application Procedures
First dissolved in DMSO (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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