Vismodegib, Hedgehog signaling pathway inhibitor (TBI2182)
$108.00 – $360.00
Hedgehog signaling pathway inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2182-5MG | Yes | 5 MG | $108.00 | |||
TBI2182-25MG | Yes | 25 MG | $360.00 |
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Description
Product Details
Formal Name: 2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide
Alternate Names: GDC-0449
Molecular Formula: C19H14Cl2N2O3S
Formula Weight: 421.30
CAS Number: 879085-55-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 200 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Hedgehog signaling pathway inhibitor
Functions
A potent and selective Hedgehog (Hh) pathway signaling inhibitor antagonizing SMO with a Ki of 1.3 nM). Alters intracellular Ca2+ homeostasis and inhibits growth of cisplatin-resistant lung cancer cells. Inhibits two ABC transporters, ABCG2/BCRP and ABCB1/Pgp, IC50s=1.4 and 3.0 μM respectively. Clinically useful for the treatment of basal cell carcinoma. Inhibits proliferation and induces apoptosis in colon cancer cell lines.
Application Procedures
First dissolved in DMSO (up to 200 mg/ml) or in Ethanol (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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