NLG919, IDO pathway inhibitor (TBI4564)
$108.00 – $405.00
IDO pathway inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4564-5MG | Yes | 5 MG | $108.00 | |||
TBI4564-25MG | Yes | 25 MG | $405.00 |
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Description
Product Details
Formal Name: 1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol
Molecular Formula: C18H22N2O
Formula Weight: 282.39
CAS Number: 1402836-58-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 10 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
IDO pathway inhibitor
Functions
NLG919 (1402836-58-1) is a potent IDO-pathway inhibitor (Ki = 7nM; EC50 = 75nM). It synergizes with chemo-radiation therapy to promote T cell dependent complement deposition in a murine model of glioblastoma. In combination with paclitaxel in a mouse B16-F10 melanoma model, NLG919 increased the percentage of CD3+, CD8+, and CD4+ T cells and secretion of IFN-γ and interleukin-2 while decreasing the percentage of CD4+CD25+ regulatory T cells.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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