CUR61414, Hedgehog pathway antagonist (TBI1392)
$162.00 – $648.00
Hedgehog pathway antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1392-5MG | Yes | 5 MG | $162.00 | |||
TBI1392-25MG | Yes | 25 MG | $648.00 |
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Description
Product Details
Formal Name: N-[(3S,5S)-1-(1,3-Benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethylbutanamide
Molecular Formula: C31H42N4O5
Formula Weight: 550.71
CAS Number: 334998-36-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Hedgehog pathway antagonist
Functions
Novel Hedgehog signaling pathway inhibitor (IC50=100-200 nM). Selectively binds to Smo but not other GPCRs. Blocks the formation of and induces the regression of basaloid lesions in skin punches and shrinks UV-induced basaloid lesions in adult mouse skin. Cell permeable.
Application Procedures
First dissolved in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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