BPTES, Glutaminase GLS1 inhibitor (TBI5414)
$99.00 – $396.00
Glutaminase GLS1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5414-5MG | Yes | 5 MG | $99.00 | |||
TBI5414-25MG | Yes | 25 MG | $396.00 |
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Description
Product Details
Formal Name: N,N’-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide
Molecular Formula: C24H24N6O2S3
Formula Weight: 524.70
CAS Number: 314045-39-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (10 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Glutaminase GLS1 inhibitor
Functions
A potent and selective allosteric inhibitor of kidney-type glutaminase (GLS1), IC50 = 3.3 µM. Selective for GLS1 over GLS2, ɣ-glutamyl transpeptidase and glutamate dehydrogenase. Shuts down an alternative energy-generating glutaminolysis pathway in P493 cells under both glucose deprivation or hypoxia. Reduces the growth of P493 cell xenografts by 50% over a 10 day treatment. BPTES inhibition of glutamine utilization in cancer cells increases PD-L1 expression. Clears senescent cells and improves various age-related disorders in a geriatric mouse model.
Application Procedures
First dissolved in DMSO (10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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