DPN, Estrogen ER b agonist (TBI2909)
$90.00 – $270.00
Estrogen ER b agonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2909-5MG | Yes | 5 MG | $90.00 | |||
TBI2909-25MG | Yes | 25 MG | $270.00 |
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Description
Product Details
Formal Name: 2,3-bis(4-Hydroxyphenyl)-propionitrile
Alternate Names: Diarylpropionitrile
Molecular Formula: C15H13NO2
Formula Weight: 239.27
CAS Number: 1428-67-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Estrogen ER b agonist
Functions
Potent estrogen ERβ receptor agonist. Displays a 70-fold selectivity over ERα, EC50 = 0.85 and 66 nM, respectively. Regulates expression of GluR1, 2 and 3 in rat hippocampus. Ameliorates portal hypertension in a carbon tetrachloride-induced liver cirrhosis rat model. Stimulates proliferation of androgen-independent prostate cancer cell line PC-3 via a novel pathway involving ERβ-mediated activation of β-catenin. A useful tool for elucidating the biological function of ERβ.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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